Enantiospecific determination of arotinolol in rat plasma by LC-MS/MS: Application to a stereoselective pharmacokinetic study

- LC-MS/MS separation of R/S-arotinolol in rat plasma was achieved within 11 min.
- 96-Well plate SPE procedure increased the sample throughput.
- The method has been applied to a pharmacokinetics study of racemic arotinolol.
- There existed no stereoselective pharmacokineitcs of arotinolol enantiomers in rats.