Comparative investigation of in vitro biotransformation of 14 components in Ginkgo biloba extract in normal, diabetes and diabetic nephropathy rat intestinal bacteria matrix

- The biotransformation of GBE in DM/DN intestinal bacteria has not been recognized.
- 14 components from GBE in intestinal bacteria were first quantified by LC-MS/MS.
- The transformation of GBE in pathological intestinal bacteria was first obtained.
- The DM/DN pathological conditions altered the biotransformation process of GBE.