Quantitative method for the determination of iso-fludelone (KOS-1803) in human plasma by LC-MS/MS

- Iso-fludelone (KOS-1803) is a synthetic third generation epothilone in phase I trials.
- An LC-MS/MS assay from 0.1 to 300 ng/mL in 0.2 mL plasma was validated and applied.
- This assay is currently utilized to quantitate iso-fludelone in clinical samples.