Solid-phase dispersive extraction method for analysis of benzodiazepine drugs in serum and urine samples

- Benzodiazepine drugs were quantified in human serum and urine by LC/TOF-MS.
- Sample preparation was performed by solid-phase dispersive extraction (SPDE).
- Solid-phase gels immediately reached equilibrium, resulting in rapid extraction.
- SPDE is simple, and superior to conventional solid-phase extraction for cleanup.
- This SPDE-LC/TOF-MS method is useful in forensic science and emergency medicine.