Direct analysis in real time mass spectrometry, a process analytical technology tool for real-time process monitoring in botanical drug manufacturing

- DART-MS was proposed as a PAT tool for real-time monitoring of percolation process.
- MPLS model was established to detect and diagnose the batch variations.
- Process faults were explained by variable contributions of effective compositions.
- DART-MS was proven to be a potential PAT tool for samples in complex matrices.