Development of novel chiral capillary electrophoresis methods for the serotonin receptor (5-HT2A) antagonist MDL 100,907 (volinanserin) and for its key intermediate compound

- Chiral CE methods for (R)-MDL 100,907 and its key intermediate were developed.
- Carboxymethylated γ- and sulfobuthylated β-cyclodextrins were good selectors.
- pKa were calculated and analytes were separated in fully protonated state.
- Stabilities and mobilities of CD complexes were determined for method optimization.
- Method applicability was checked.