Parallel achiral-chiral determination of oxybutynin, N-desethyl oxybutynin and their enantiomers in human plasma by LC-MS/MS to support a bioequivalence trial

- Parallel achiral and chiral determination of oxybutynin and metabolite in plasma.
- Use of deuterated IS for any variability during extraction and LC-MS/MS analysis.
- Optimized methods are rugged and practically free from matrix interference.
- First report on enantiomeric pharmacokinetics in healthy Indian subjects.
- Method reproducibility is demonstrated by incurred sample reanalysis.