Pharmacokinetics study of hemin in rats by applying 58Fe-extrinsically labeling techniques in combination with ICP-MS method

- Hemin was extrinsically labeled by 58Fe avoiding endogenous interference.
- Mass spectrometric conditions were optimized using collision cell technology.
- A mathematical correction equation was used to compensate for interference.
- Isotope concentration, not ratio was treated as information for absorption study.
- A new ICP-MS method was developed for pharmacokinetic study of iron preparations.