How to address the sample preparation of hydrophilic compounds: Determination of entecavir in plasma and plasma ultrafiltrate with novel extraction sorbents

- Determination of entecavir in rat plasma and plasma ultrafiltrate samples.
- Microextraction by packed sorbent as the semi-automatic sample preparation method.
- The choice of suitable sorbents for the extraction of polar compounds (MCX and PGC sorbents).
- Application to real plasma and plasma ultrafiltrate samples to evaluate pharmacokinetic profiles of entecavir.