Determination of androgen receptor degradation enhancer ASC-J9® in mouse sera and organs with liquid chromatography tandem mass spectrometry

- A simple LC-MS/MS method for the quantification of ASC-J9® in mouse serum was developed.
- Stability tests in different matrices were conducted to validate the types of samples to be analysed.
- Method was applied to study the pharmacokinetics of ASC-J9® in mouse serum samples.
- Method was also used to find the distribution of drug in mice organs.