Evaluation of supercritical fluid chromatography for testing of PEG adducts in pharmaceuticals

- Reaction between PEG 400 and 2 APIs resulted in formation of PEG adducts.
- Separation of PEG adducts was performed with supercritical fluid chromatography.
- Cetirizine was more reactive towards PEG 400 than indomethacin.
- Detection with mass spectrometry is well-suited for identification of PEG adducts.