Development and validation of a high-performance liquid chromatography-tandem mass spectrometry assay quantifying vemurafenib in human plasma

- This assay was fully validated according to the latest FDA and EMA guidelines.
- The validation is compliant with the OECD principles of Good Laboratory Practice.
- Two different LC-MS/MS systems were tested and compared.
- This assay is now used for TDM and clinical trials with vemurafenib.