Simultaneous investigation of sesquiterpenes, pyrrolizidine alkaloids and N-oxides in Butterbur (Petasites hybridus) with an offline 2D-combination of HPLC-UV and LC-MMI-ToF-MS

- Offline 2D-analysis of Petasites hybridus (Butterbur) by HPLC-UV and LC-MMI-ToF-MS.
- Medicinal and hepatotoxic constituents in its ethanolic extract.
- Introduction of an analytical strategy using complementary LC-MS methods.
- Relation between calculated log D, hydrophobicity distributions and retention times.