LC-MS/MS-based quantification of clinically relevant intestinal uptake and efflux transporter proteins

- LC-MS/MS methods for ten drug transporters (ABCB1, ABCC2, ABCC3, ABCG2, OATP1A2, OATP2B1, PEPT1, ASBT, OCT1 and OCT3).
- First quantitative assays for ABCC3, OATP1A2, PEPT1, ASBT, OCT1 and OCT3.
- Comprehensive method validation for all transporters.
- Application to analyze human intestinal transporter expression; first comprehensive human intestinal expression data.
- mRNA and protein expression data from human jejunum and ileum.