High-throughput NIR-chemometric methods for determination of drug content and pharmaceutical properties of indapamide tablets

► A NIR-chemometric method was developed and validated for direct assay of indapamide in tablets. ► A NIR-chemometric method was developed and validated for disintegration time determination of indapamide tablets. ► A NIR-chemometric method was developed and validated for crushing strength determination of indapamide tablets. ► The methods are appropriate for direct prediction of both chemical and pharmaceutical properties of indapamide tablets.