کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7631856 | 1494652 | 2013 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A rapid, accurate and robust UHPLC-MS/MS method for quantitative determination of BMS-927711, a CGRP receptor antagonist, in plasma in support of non-clinical toxicokinetic studies
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A rapid, accurate and robust UHPLC-MS/MS method for quantitative determination of BMS-927711, a CGRP receptor antagonist, in plasma in support of non-clinical toxicokinetic studies A rapid, accurate and robust UHPLC-MS/MS method for quantitative determination of BMS-927711, a CGRP receptor antagonist, in plasma in support of non-clinical toxicokinetic studies](/preview/png/7631856.png)
چکیده انگلیسی
- A robust assay was validated to quantify BMS-927711, a drug candidate, in plasma.
- A simplified method optimization strategy was used to develop this robust assay.
- An N-carbamoyl glucuronide metabolite was evaluated to minimize its conversion risk.
- Excellent assay robustness, precision and accuracy were achieved.
- It has been applied to non-clinical toxicokinetic studies in different species.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 83, September 2013, Pages 237-248
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 83, September 2013, Pages 237-248
نویسندگان
Naiyu Zheng, Jianing Zeng, Billy Akinsanya, Adela Buzescu, Yuan-Qing Xia, Van Ly, Kevin Trouba, Qianping Peng, Anne-Françoise Aubry, Mark E. Arnold,