A selective and sensitive UPLC-MS/MS approach for trace level quantification of four potential genotoxic impurities in zolmitriptan drug substance

- First report on simultaneous determination of four PGIs in zolmitriptan.
- The developed UPLC-MS/MS method is highly sensitive and fully validated.
- The detection levels of all four impurities are found to be very low.
- The method is successfully applied for formulation batches of zolmitriptan.