Redox-proteomic analysis of doxorubicin resistance-induced altered thiol activity in uterine carcinoma

► Doxorubicin-induced drug resistance is one of the most serious obstacles in cancer chemotherapy. ► Cysteine-labeling based 2D-DIGE was employed to analyze redox regulation in uterine cancer. ► 33 unique protein features that were significantly changed in thiol reactivity were identified. ► The identified targets may contribute on the formation of drug resistance.