A UPLC-MS/MS method for the simultaneous plasma quantification of all isomeric forms of the new anti-HCV protease inhibitors boceprevir and telaprevir

► First method to simultaneously quantify telaprevir and boceprevir isomers. ► We use human acidified plasma, avoiding the transition from one isomer to another. ► The first time use of UPLC-MS/MS, allowing a short and high selective run. ► We use a easy to buy and cheap IS (quinoxaline). ► The extraction procedure is very fast and cheap (No SPE cartridges).