Pharmacokinetics and tissue distribution study of schisandrin B in rats by ultra-fast liquid chromatography with tandem mass spectrometry

► Development of an UFLC-MS/MS method to determine schisandrin B in biological matrix. ► Pharmacokinetic curve of schisandrin B showed double peaks in rat plasma. ► Schisandrin B was mainly accumulated in liver in rats. ► Renal excretion might be a main elimination route for schisandrin B in rats.