Development of the high-performance liquid chromatographic method for the enantioseparation of unusual glycine ester analogs on polysaccharide-based chiral stationary phases

► Separation of glycine ester analogs on polysaccharide-based CSPs. ► Structure-retention relationships of separation based on size-descriptor (Meyer) parameters. ► Thermodynamics of separation of glycine ester analogs. ► Entropically controlled chiral separation.