کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7632370 1494657 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of LC-MS/MS method for the simultaneous analysis of the cardioprotective drug dexrazoxane and its metabolite ADR-925 in isolated cardiomyocytes and cell culture medium
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Development of LC-MS/MS method for the simultaneous analysis of the cardioprotective drug dexrazoxane and its metabolite ADR-925 in isolated cardiomyocytes and cell culture medium
چکیده انگلیسی
► Dexrazoxane (DEX) is a highly effective, clinically used cardioprotective drug. ► Its mechanism of action still remains elusive. ► This is caused by difficulties with assay of DEX along its active metabolite. ► The first LC-MS/MS method for their simultaneous determination was developed. ► This method was validated and finally utilized in the relevant in vitro experiment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 76, 25 March 2013, Pages 243-251
نویسندگان
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