Detection of some volatile degradation products released during photoexposition of ranitidine in a solid state

► This work presents photostability testing of ranitidine in a solid state. ► Detection of some volatile organic compounds is proposed. ► HS-SPME-GC-MS was employed as a powerful tool. ► Sixteen peaks were detected in the headspace over irradiated ranitidine. ► Most of the suspected products' molecular masses were not higher than 143 Da.