High-throughput NIR-chemometric methods for determination of drug content and pharmaceutical properties of indapamide powder blends for tabletting

► NIR-chemometric method was developed and validated for direct assay of indapamide in powder blends for tabletting. ► NIR-chemometric method was developed for granulometric analysis of powder blends for tabletting. ► NIR-chemometric method was developed for flowability assessment of powder blends for tabletting. ► The methods are appropriate for direct assay of both chemical and pharmaceutical properties of powder blends for tabletting.