Apport de l'immunologie à la prise en charge diagnostique et thérapeutique des glomérulonéphrites extramembraneuses

From now on, idiopathic membranous nephropathy could be ascertained as autoimmune disease, since autoantibodies were isolated against glomerular components, or even against usual dietary antigens. Some of them, like anti-PLA2R antibodies or anti-THSD7A are useful to monitor the disease activity and to follow the treatment efficacy. Genetic polymorphisms of PLA2R gene may be the underlying cause of idiopathic membranous nephropathy. This translational research opens a new field to develop innovative targeted therapies.