کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7650359 1495063 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anatomopathologie du rejet de greffe humoral en transplantation rénale et cardiaque
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Anatomopathologie du rejet de greffe humoral en transplantation rénale et cardiaque
چکیده انگلیسی
Humoral rejection (antibody-mediated rejection, ABMR) is a major concern in solid organ transplantation, playing a key role in late allograft losses. ABMR is mediated by anti HLA antibodies found in the serum of the recipient and directed against the donor (donor specific antibodies - DSA). Activation of the classical pathway of the complement cascade triggered by the fixation of the antibodies on endothelial cells is the main pathogenic feature of ABMR, responsible for the histological lesions. Diagnostic criteria are well established in kidney and cardiac transplantation based on the presence of histological criteria, mainly inflammation of the microcirculation, DSA and positivity of C4d. In other solid organ transplantations, ABMR is a more recent entity and diagnostic criteria are less clear.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revue Francophone des Laboratoires - Volume 2014, Issue 458, January 2014, Pages 41-49
نویسندگان
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