کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7650680 1495064 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rôle des plaquettes réticulées dans le diagnostic différentiel des thrombocytopénies
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Rôle des plaquettes réticulées dans le diagnostic différentiel des thrombocytopénies
چکیده انگلیسی
Reticulated platelets (RP) are the youngest circulating platelets with higher mRNA content. The percentage of RP (RP %) reflect the rate of bone marrow platelet regeneration. In the present study, we measured RP % in 22 patients with thrombocytopenia (10 patients with idiopathic thrombocytopenia purpura and 12 aplastic patients after chemotherapy) and in 35 normal subjects. RP % was performed by whole blood flow cytometry using double staining : anti CD41 and thiazole orange. The RP % in normal subjects was 2.1 % ± 1.9 %. It was observed that the RP % was significantly higher in patient with idiopathic thrombocytopenia purpura than normal subjects than aplastic patients after chemotherapy (31.74 % ± 18.26 % vs 2.1 % ± 1.9 % vs 0.51 % ± 0.19 %); p < 0.01). The RP determination is thought to be a useful marker for estimating thrombopoiesis in bone marrow and for differential diagnosis of thrombocytopenic disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revue Francophone des Laboratoires - Volume 2013, Issue 457, December 2013, Pages 61-65
نویسندگان
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