Infection à Helicobacter pylori et cancer gastrique

The evolution towards gastric cancer can be due to genetic factors, e.g. polymorphisms of certain cytokine genes, to environmental factors (salt consumption, meat diet…) but the bacterial factors have a major role. Some H. pylori strains harbor a pathogenicity island, the so-called cagPAI, and produce the CagA oncoprotein which modifies the epithelial cell signaling pathways and is essential in the cell transformation.