کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7651921 | 1495069 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Différenciation lymphocytaire B normale
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
B lymphocytes transform into antibody-producing cells in response to a specific antigenic stimulus. However, it has been shown that production of antibodies can alternatively be triggered by other stimuli, explaining at least in part the efficacy of Rituximab in auto-immune diseases. B lymphocytes rearrange the genes coding for the chains of immunoglobulins in the bone marrow, during B-lymphopoiesis. Epigenetic phenomenon regulating this process are increasingly recognized. B lymphocytes exit the bone marrow as transitional B lymphocytes which turn rapidly in naïve B-cells. Part of those cells recirculate in blood and peripheral lymphoid organs until they encounter the antigen of which their BCR is specific. From there on, they can mount a specific response against the antigen, transform into antibody-producing cells, either directly, or by undergoing the process of germinal centre differenciation which will lead to Immunoglobulin-class switch and somatic hypermutation. Some of them will remain in the long term as memory B-cell or plasma cells. Other B-lymphocytes spontaneously secrete natural IgM, others can be stimulated by Toll-like-receptors, as innate immune cells do, and will respond by proliferation and/or transforming into cells able to produce high levels of antibodies. Finally, some naïve B-cells join the marginal zones of secondary lymphoid organs and will lead to a quick production of IgM in response to encapsulated bacteria.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revue Francophone des Laboratoires - Volume 2013, Issue 452, May 2013, Pages 27-35
Journal: Revue Francophone des Laboratoires - Volume 2013, Issue 452, May 2013, Pages 27-35
نویسندگان
Anne Plonquet,