Dosage de la testostérone plasmatique : difficultés méthodologiques et intérêt physiopathologique

Testosterone circulates in blood mostly bound to proteins, with high affinity and specificity to SHBG and non specifically to albumin, from which it dissociates rapidly. Only 1-3% of serum testosterone is free. For clinical studies, assays of total plasma testosterone, free testosterone or bio-available testosterone can be achieved.