کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7661985 | 1495121 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Difficultés d'interprétation en toxicologie : identification plasmatique de sulfamides hypoglycémiants et hypoglycémies inexpliquées
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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![عکس صفحه اول مقاله: Difficultés d'interprétation en toxicologie : identification plasmatique de sulfamides hypoglycémiants et hypoglycémies inexpliquées Difficultés d'interprétation en toxicologie : identification plasmatique de sulfamides hypoglycémiants et hypoglycémies inexpliquées](/preview/png/7661985.png)
چکیده انگلیسی
Hypoglycemia crisis of unknown origin can be induced by factitious sulfonylurea ingestion which as been described as Munchausen syndrom. It is essentiel to distinguish from an insulin-secreting tumor, and diagnostic can be done by using a method for identification of sulfonylureas in human plasma. Different analytical techniques have been used : most methods are based on HPLC with ultra-violet, or diode array which is more specific. More recently, highly selective liquid chromatography-electrospray tandem mass spectrometry (MS-MS) has been described for rapid screening. We report the case of hypoglycemic crises in a 38 years old woman. HPLC-DAD was used after liquid/liquid extraction of plasma and urine samples. Identification of gliclazide was done in three plasma samples but not in urine. This HPLC-DAD assay can be highly convenient but need plasma sampling at a time period closed from hypoglycemic crise.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revue Francophone des Laboratoires - Volume 2008, Issue 406, November 2008, Pages 39-42
Journal: Revue Francophone des Laboratoires - Volume 2008, Issue 406, November 2008, Pages 39-42
نویسندگان
Christophe Bardin, Naïma Tafzi,