Évaluation Non Invasive de la Fibrose Hépatique au Cours des Hépatites Chroniques Virales C

Some usual parameters such as transaminasea, platelets, prothrombin time, have been described as indirect fibrosis markers. More recently, improvement of knowledge about fibrogenesis mechanisms allowed identifying circulating substances able to become new direct fiver fibrosis markers. Components of extra cellular matrix, degradation products or metabolism enzymes have been proposed. Among them, hyaluronic acid seems to be of great interest. Moreover, some scores have been calculated from these parameters and validated in clinical situations such as C hepatitis. Fibrotest® is the more often used. Finally, Fibroscan@, which is a medical device for diagnosis and assessment of fiver fibrosis based on elastography, has been proposed. The relative interest of these markers has to précised.