کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
76697 49146 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of mesoporous silicates on carbamazepine dissolution rate enhancement
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
پیش نمایش صفحه اول مقاله
Role of mesoporous silicates on carbamazepine dissolution rate enhancement
چکیده انگلیسی

Carbamazepine is an antiepileptic drug characterized by poorly water solubility that affects negatively its bioavailability. Here we report on the ability of the mesoporous silicate MCM-41 to act as a vehicle able to improve the drug dissolution rate by preventing drug crystallization. Carbamazepine was adsorbed into nanopores of MCM-41 and the drug loaded MCM-41 was characterized by X-ray powder diffraction, N2 adsorption, FT-IR spectroscopy and thermogravimetric and differential scanning calorimetry analyses. Carbamazepine loading resulted 14% and the drug was not arranged in crystalline form. In vitro drug release results showed a remarkable increase of carbamazepine dissolution rate in all the different tested media. As this improvement is due both to the high specific surface area of loaded MCM-41 and to the lack of crystalline drug, storage stability studies at different environment conditions were conducted in order to investigate the ability of MCM-41 to prevent drug crystallization.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microporous and Mesoporous Materials - Volume 113, Issues 1–3, 1 August 2008, Pages 445–452
نویسندگان
, , , , , , ,