کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
76697 | 49146 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Role of mesoporous silicates on carbamazepine dissolution rate enhancement Role of mesoporous silicates on carbamazepine dissolution rate enhancement](/preview/png/76697.png)
Carbamazepine is an antiepileptic drug characterized by poorly water solubility that affects negatively its bioavailability. Here we report on the ability of the mesoporous silicate MCM-41 to act as a vehicle able to improve the drug dissolution rate by preventing drug crystallization. Carbamazepine was adsorbed into nanopores of MCM-41 and the drug loaded MCM-41 was characterized by X-ray powder diffraction, N2 adsorption, FT-IR spectroscopy and thermogravimetric and differential scanning calorimetry analyses. Carbamazepine loading resulted 14% and the drug was not arranged in crystalline form. In vitro drug release results showed a remarkable increase of carbamazepine dissolution rate in all the different tested media. As this improvement is due both to the high specific surface area of loaded MCM-41 and to the lack of crystalline drug, storage stability studies at different environment conditions were conducted in order to investigate the ability of MCM-41 to prevent drug crystallization.
Journal: Microporous and Mesoporous Materials - Volume 113, Issues 1–3, 1 August 2008, Pages 445–452