Novel method for manipulation of anion-exchange selectivity by derivatizing hydroxyl groups in the proximity of quaternary nitrogen ion-exchange sites with glycidol

A general approach for the manipulation of anion-exchange selectivity through derivatization of hydroxyl groups adjacent to quaternary anion-exchange sites with glycidol is described. Repetitive reactions with glycidol result in dramatic shifts in the retention of divalent anions. Unique selectivities are observed for specific divalent species resulting in shifts in elution order. Modification of anion-exchange materials with glycidol has a small effect on the selectivity of monovalent anions, but in some cases, significant shifts in selectivity are observed. Use of the synthetic approach for modification of commercially available ion-exchange materials is demonstrated.