Study of Abl1 tyrosine kinase inhibitors by liquid chromatography-electrospray ionization-mass spectrometry

► An inhibitor study model using LC/MS was established and validated. ► This assay was applied successfully to study inhibitors of Abl1. ► 3 groups of compounds were tested: commercial drugs, polyphenols and MPB. ► Polyphenols have inhibitory activity against Abl1.