Facile synthesis of Fe3O4@mesoporous TiO2 microspheres for selective enrichment of phosphopeptides for phosphoproteomics analysis

► In this work we synthesized Fe3O4@mesoporous TiO2 microspheres. ► They have large surface area, good dispersivity and biocompatibility. ► They were used for selective enrichment of phosphopeptides. ► Both standard peptides and biological sample brain tissue were used for research. ► They have been demonstrated as a powerful tool to phosphoproteomics research.