Greener liquid chromatography using a guard column with micellar mobile phase for separation of some pharmaceuticals and determination ofparabens

► Guard column was used for HPLC separation of some pharmaceuticals and parabens. ► High separation efficiency was achieved with guard column and micellar mobile phase. ► Low cost guard cartridge and non-toxic mobile phase were used. ► The system gains lower chemical consumption and waste generation. ► Short analysis time and simple sample preparation were achieved.