Isolation/separation of plasmid DNA using hemoglobin modified magnetic nanocomposites as solid-phase adsorbent

► Hemoglobin (Hb) modified magnetic nanocomposites were prepared as a novel adsorbent. ► Hb was immobilized onto the surface of amino-functionalized Fe3O4@SiO2 magnetic nanoparticles. ► The composites provide comparable yield of plasmid DNA with respect to those obtained by commercial kits.