Development of a fluid bed granulation process control strategy based on real-time process and product measurements

► This manuscript describes the work performed in 3 fluid bed granulation (FBG) case studies. ► In-line size (SFV, FBRM) and moisture (NIR) analyzers were applied in FBG. ► Real-time monitoring of granule characteristics and endpoint detection. ► Development of an FBG feed-forward control strategy.