Novel hybrid organic-inorganic monolithic column containing mesoporous nanoparticles for capillary electrochromatography

► A novel monolithic stationary phase combining nanoparticles was developed. ► The surface area of monolith is significantly increased by adding nanoparticles. ► Incorporation of nanoparticles enhances both selectivity and column efficiency. ► The mechanism is mixed mode of reverse phase and ion exchange.