Measurement of yunaconitine and crassicauline A in small-volume blood serum samples by LC-MS/MS: Tracing of aconite poisoning in clinical diagnosis

► New LC-MS/MS method for yunaconitine and crassicauline A detection in blood matrix. ► High method specificity can reduce endogenous and exogenous interference. ► Results showed that this method can be utilized in clinical routine applications.