Monitoring the subcellular localization of doxorubicin in CHO-K1 using MEKC−LIF: Liposomal carrier for enhanced drug delivery

► Subcellular fractionation was achieved by differential centrifugation. ► Combo of LLE and MEKC-LIF could be a powerful tool for monitoring intracellular DOX distribution. ► Better therapeutic effect of liposomal DOX was due to the efficient drug delivery to cell nucleus.