A novel reverse phase stability indicating RP-UPLC method for the quantitative determination of fifteen related substances in Ranolazine drug substance and drug product

► Separation of 15 process related impurities with in 15 min. ► New stability indicating method for Ranolazine by using UPLC. ► Method has capability of separating major oxidative degradant di-N-Oxide impurity. ► New method for the separation of regio isomers of Ranolazine. ► designed to determine impurities in drug substance as well as in the drug product.