Expanding the linear dynamic range for multiple reaction monitoring in quantitative liquid chromatography-tandem mass spectrometry utilizing natural isotopologue transitions

► A very wide linear dynamic range (LDR) is often necessary in pharmacokinetic (PK) studies. ► Isotopologues occur naturally for all synthesized compounds. ► In LC-MS/MS, most commonly used with PK studies, monitoring corresponding transitions for isotopologues provide a powerful way to increase the LDR.