Solid phase microextraction, mass spectrometry and metabolomic approaches for detection of potential urinary cancer biomarkers-A powerful strategy for breast cancer diagnosis

► SPME useful to establishment of urinary volatile metabolomic pattern. ► Explore the VOMs as potential biomarkers in breast cancer diagnosis at early stage. ► Positive rates of 6 VOMs among the 79 detected were statistically different (p < 0.05). ► Very good discrimination within breast cancer and control groups was achieved.