کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7687971 1495868 2018 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dried matrix spots and clinical elemental analysis. Current status, difficulties, and opportunities
ترجمه فارسی عنوان
نقاط ماتریکس خشک و تجزیه و تحلیل عناصر بالینی. وضعیت فعلی، مشکلات و فرصت ها
کلمات کلیدی
لکه های ماتریکس خشک شده لکه های خون خشک شده لکه های ادرار خشک شده تجزیه و تحلیل عنصر ردیابی، آنالیز ایزوتوپ، نمونه برداری جامد،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
This article examines the increasing importance of dried matrix spots (DMS), such as dried blood spots, dried urine spots, etc., in biomedical research, the challenges associated with their analysis when quantitative elemental information is aimed at, as well as the benefits deriving from the further usage of these types of samples. The article briefly reviews the historical evolution of this sampling approach in elemental clinical analysis, stressing prospective areas of applications (e.g., newborns or prosthesis control), the methodologies most recently developed to produce DMS of known volume, as well as novel strategies proposed to analyze them, often related to direct solid sampling techniques or fast lixiviation methods. Finally, the article discusses the type of information that could be obtained after isotopic analysis of DMS when targeting non-traditional stable isotopes (e.g., Cu, Fe or Zn), which can significantly help in the early diagnosis of some medical conditions (e.g. Wilson's disease).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: TrAC Trends in Analytical Chemistry - Volume 99, February 2018, Pages 75-87
نویسندگان
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