کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7689825 1495901 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hydrophilic interaction chromatography of polar and ionizable compounds by UHPLC
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Hydrophilic interaction chromatography of polar and ionizable compounds by UHPLC
چکیده انگلیسی
In recent years, the popularity of hydrophilic interaction chromatography (HILIC) in the analysis of small polar and ionizable molecules increased substantially. A large number of new stationary phases with sub-2-µm and superficially porous particles were developed and used in various applications, including pharmaceuticals, metabolites, biomarkers, amino acids and peptides. Applications of HILIC in ultra-high performance liquid chromatography (UHPLC) mode constitute only about 10% of all current HILIC applications. This review presents an overview of UHPLC in HILIC mode, including the importance of the final sample diluent, a discussion on available stationary phases and approaches to detection, and a comparison of performance with other chromatographic modes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: TrAC Trends in Analytical Chemistry - Volume 63, December 2014, Pages 55-64
نویسندگان
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