کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7689918 1495901 2014 33 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Investigation of pharmaceuticals and illicit drugs in waters by liquid chromatography-high-resolution mass spectrometry
ترجمه فارسی عنوان
بررسی داروها و مواد مخدر در آب با کروماتوگرافی مایع و طیف سنجی جرمی با وضوح بالا
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Mass spectrometry (MS) coupled to chromatography has been increasingly used in the environmental field, as it allows the best performance currently attainable for the investigation of a wide range of organic pollutants. When dealing with emerging contaminants, there is a clear trend towards the use of liquid chromatography-mass spectrometry (LC-MS) techniques, from tandem (low-resolution) MS to high-resolution (HR) MS. HRMS allows targeted and untargeted analysis, thanks to full-spectrum acquisition at high mass accuracy with good sensitivity. With the same instrument, target, suspect and non-target screening can be performed, as can retrospective analysis and discovery of transformation/degradation products. This article gives a general overview on the use of HRMS in LC-based methods directed towards the investigation of illicit drugs and pharmaceuticals in the aqueous environment. We consider time-of-flight and Orbitrap mass analyzers, and we discuss the benefits of using ultra-high-performance liquid chromatography (UHPLC) in combination with HRMS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: TrAC Trends in Analytical Chemistry - Volume 63, December 2014, Pages 140-157
نویسندگان
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