کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7692389 | 1496297 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Proatherogenic modification of LDL by surface-bound myeloperoxidase
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کلمات کلیدی
Ceruloplasmin4-aminobenzoic acid hydrazide - 4-آمینوبنزوئیک اسید هیدرازیدMPO - DFOAtherosclerosis - آترواسکلروز(تصلب شریان)ABAH - ابژهCholesterol accumulation - تجمع کلسترولLDH, lactate dehydrogenase - لاکتات دهیدروژنازlow density lipoproteins - لیپوپروتئین های چگالی کمLDL - لیپوپروتئین کم چگالی(کلسترول بد)myeloperoxidase - میلوپراکسیداز
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
One of the factors promoting oxidative/halogenating modification of low-density lipoproteins (LDL) is myeloperoxidase (MPO). We have shown previously that MPO binds to the LDL surfaces. The LDL-MPO complex is uncoupled in the presence of peptide EQIQDDCTGDED that corresponds to a fragment of apoB-100 (445-456). In this paper we studied how this peptide, as well as inhibitors and modulators of halogenating activity of MPO such as ceruloplasmin (CP), 4-aminobenzoic acid hydrazide (ABAH) and thiocyanate (SCNâ) affect the accumulation of cholesterol and its esters in monocytes/macrophages after incubation with LDL subjected to different kinds of MPO-dependent oxidative/halogenating modification. In the presence of H2O2 and halides MPO causes stronger proatherogenic modification of LDL than exogenous reactive halogen species (HOCl and HOBr). Both monocytes, which differentiate into macrophages, and neutrophils secrete MPO in response to the presence of damaged LDL. The peptide EQIQDDCTGDED preventing interaction between MPO and LDL reduces the uptake of modified LDL and MPO by monocytes/macrophages and thus precludes the accumulation of intracellular cholesterol. Our results indicate that binding to MPO is important for LDL to become modified and acquire proatherogenic properties. The peptide EQIQDDCTGDED, CP, ABAH, and SCNâ can play the role of anti-atherogenic factors reducing the deleterious effect of catalytically active MPO on LDL and accumulation of cholesterol in macrophages.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemistry and Physics of Lipids - Volume 180, May 2014, Pages 72-80
Journal: Chemistry and Physics of Lipids - Volume 180, May 2014, Pages 72-80
نویسندگان
Alexej V. Sokolov, Valeria A. Kostevich, Olga L. Runova, Irina V. Gorudko, Vadim B. Vasilyev, Sergej N. Cherenkevich, Oleg M. Panasenko,