Determining the effect of the incorporation of unnatural amino acids into antimicrobial peptides on the interactions with zwitterionic and anionic membrane model systems

► These AMPs interact with anionic and zwitterionic membranes via different mechanisms. ► There are detectable differences between how these AMPs interact with the membrane models. ► The curvature and other properties of SUVs effects the conformations adopted by these AMPs. ► The length of Spacer #1, particularly for compound 39, defines organism selectivity and potency.